Patrick Mahomes holds the second-highest winning percentage in NFL history. Yet, one statistic continues to puzzle his fans: he has never beaten the Indianapolis Colts in a regular-season game.
In both 2019 and 2022, Mahomes faced the Colts—and both times, the Kansas City Chiefs came up short, despite his combined 583 passing yards and two touchdown passes. Could history repeat itself in their third meeting?
A strong performer, but a troubling pattern
According to The Sports Rush, the Kansas City Chiefs will face the Indianapolis Colts in Week 12 of the 2025–26 NFL season. The big question: Can Mahomes finally break this streak? Especially considering that Indianapolis has started the season strong, winning several of their first five games.
That means Mahomes will not have an easy task ahead. The matchup, scheduled for November 23, will likely be crucial as both teams aim for the playoffs. It promises to be a tight and high-stakes battle for the Chiefs’ star quarterback.
The top 5 highest scoring NFL teams after TNF pic.twitter.com/V1gRkAORp8
— Drew Cook (@CooksCoverage) October 3, 2025
In their 2019 matchup, Mahomes managed only two total touchdowns, and the Chiefs relied on several field-goal attempts. The Colts claimed a 19–13 victory. Their next meeting in 2022, held at Lucas Oil Stadium, followed a similar script.
That time, Kansas City led 17–10 before the final quarter, but the Colts executed a series of smart plays that dismantled the Chiefs’ defense and allowed Matt Ryan to orchestrate a comeback win.
With those results in mind, Mahomes and his team will need to give everything they’ve got in November to finally defeat Indianapolis. This year’s Colts squad looks more dangerous and competitive than ever, posing a serious test for one of the league’s greatest quarterbacks.
